


If you want to eventually print your drawing at 16" x 20", then you need to start with a document that big, at a resolution of at least 150 ppi (depending on how it will be printed). If you draw in Photoshop it is important to plan ahead for final output size. Photoshop drawings can be more similar to drawing with traditional media like pencils, or chalk, or paint, if that's what you want. The lines are very clean and sharp, which is great for logo design and illustration. Illustrator drawings can be scaled and printed at any size without loss of image quality.

That means Photoshop works with pixels and Illustrator does not. Illustrator is a vector based application and Photoshop is an image editor.
